Publications

Mammalian Model System

Saifetiarova, J., Liu, X., Taylor, A.M., Li, J. and Bhat, M.A. (2017). Axonal Domain Disorganization in Caspr1 and Caspr2 Mutant Myelinated Axons Affects Neuromuscular Junction Integrity Leading to Muscle Atrophy. J. Neurosci. Res. DOI: 10.1002/jnr.24052

Saifetiarova, J., Taylor, A.M., and Bhat, M.A. (2017) Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. J Neurosci. 2661-16.2017 

Taylor, A.M., Saifetyarova, J., and Bhat, M.A. (2017) Postnatal Loss of Neurofascin 186 and Neurofascin 155 Differentially Affects the Maintenance of Nodes of Ranvier and Health of Myelinated Axons. Front. Cell. Neurosci. 11:11. doi: 10.3389/fncel.2017.00011 

Calvo, M., Richards, N., Schmid, A.B., Barroso, A., Zhu, L., Ivulic, D., Zhu, N., Anwandter, P., Bhat, M.A., Court, F.A., McMahon, S.B. and Bennett, D.L. (2016). Altered potassium channel distribution and composition in myelinated axons suppresses hyperexcitability following injury. Elife 5. pii: e12661. 

Schmid, A.B., Bland, J., Bhat, M. A., and Bennett, D.L.H. (2014). The relationship of nerve fibre pathology to sensory function in entrapment neuropathy. Brain. 2014 Oct 27. pii: awu288.

Green, J. A., Yang, J., Grati, M., Kachar, B. and Bhat, M.A. (2013). Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons. BMC Neuroscience 2013, 14:96

Buttermore, E.D., Thaxton, C. and Bhat, M.A. (2013). Organization and Maintenance of Molecular Domains in Myelinated Axons. J. Neurosci. Res.  doi: 10.1002/jnr.23197)

Grati, M., Shin, J.B., Weston, M. D., Green, J., Bhat, M. A., Gillespie, P.G., and Kachar, B. (2012). Localization of PDZD7 to the Stereocilia Ankle-Link Associates this Scaffolding Protein with the Usher Syndrome Protein Network. J. Neurosci. 32: 14288-14293.

Buttermore, E.D., Piochon, C., Wallace, M., Philpot, B., Hansel, C., and Bhat, M.A. (2012). Pinceau organization in the cerebellum requires distinct functions of Neurofascin in Purkinje and basket neurons during postnatal development.  J. Neurosci. 32, 4724-4742.

Buttermore, E.D., Dupree, J.L., Tessarollo, L. and Bhat, M.A. (2011). The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons. J. Neurosci. 31, 8013-8024.

Thaxton, C., Pillai, A.M., Pribisko, A.L., Dupree, J.L. and Bhat, M.A. (2011) Nodes of Ranvier Act as Barriers to Restrict Invasion of Flanking Paranodal Domains in Myelinated Axons. Neuron 69, 244-257.

Thaxton, C., Pillai, A.M., Pribisko, A.L., Labasque, M., Dupree, J.L., Faivre-Sarrailh, C. and Bhat, M.A. (2010). In vivo Deletion of Immunoglobulin Domains 5-6 in Neurofascin (Nfasc) Reveals Domain Specific Requirements in Myelinated Axons. J. Neurosci. 30, 4868-4876.

O'Brien, B.J., Hirano, A.A., Buttermore, E.D., Bhat, M.A. and E. Peles (2010). Localization of the Paranodal Protein Caspr in the Mammalian Retina. Mol. Vis. 16, 1854-1863.

Pomicter AD, Shroff SM, Fuss B, Sato-Bigbee C, Brophy PJ, Rasband MN, Bhat, M.A., Dupree JL. (2010). Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis. Brain 133, 389-405.

Pillai, A.M., Thaxton, C. Pribisko, A.L. Cheng, J.-G. Dupree, J.L. and Bhat, M.A. (2009). Spatio-temporal Ablation of Myelinating Glia-Specific Neurofascin (NfascNF155) in Mice Reveals Gradual Loss of Paranodal Axo-Glial Junctions and Concomitant Disorganization of Axonal Domains. J. Neurosci. Res. 87, 1773-1793. (Featured in Faculty of 1000).

Thaxton, C. and Bhat, M.A. (2009). Myelination and Regional Domain Differentiation of the Axons. Results Probl Cell Differ. 48, 1-28.

Sousa, A.D., Andrade, L.R., Salles, F.T., Pillai, A.M., Buttermore, E., Bhat, M.A. and B. Kachar. 2009. The Septate Junction Protein Caspr is Required for Structural Support and Retention of KCNQ4 at Calyceal Synapses of Vestibular Hair Cells. J Neurosci. 29, 3103- 3108.

Stokely, M.E., Garg, P., Bhat, M.A. and Koulen P. 2008. Transient 5-(4-phenylbutoxy) psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles. J Neurosci Res. 86, 2111-2124.

Einheber, S., Bhat, M.A. and J.L. Salzer. 2007. Disrupted axo-glial junctions result in accumulation of abnormal mitochondria at the nodes of Ranvier. Neuron Glia Biol. 2, 165- 174.

Pillai AM, Garcia-Fresco GP, Sousa AD, Dupree JL, Philpot BD, Bhat, M.A. 2007. No effect of genetic deletion of contactin-associated protein (CASPR) on axonal orientation and synaptic plasticity. J. Neurosci. Res. 285, 2318-2331 (featured on Cover).

Stokely, M.E., Bhat, M.A. and Koulen P. 2007. Microfluorimetry defines early axonal damage in a rat model of optic neuritis: a novel method targeting early CNS autoimmunity. J Neurosci Methods. 166, 217-228.

Sousa A.D., and Bhat, M.A. (2007). Cytoskeletal Transition at the Paranodes: The Achilles’ Heel of Myelinated Axons. Neuron Glia Biol. 3, 169-178.

McLear, J.A., G.P. Garcia-Fresco, Bhat, M.A. and T.A. Van Dyke. 2006. In Vivo Inactivation of pRb, p107 and p130 in Murine Neuroprogenitor Cells Leads to Major CNS Developmental Defects Culminating in High Siezure Rates. Mol. Cell. Neurosci. 33, 260-273.

Garcia-Fresco, G. P., Sousa, A. D., Pillai, A. M., Moy, S, Crawley, J., Tessarollo, L., Dupree, J. L., and Bhat, M.A. 2006. Disruption of axo-glial junctions cytoskeletal disorganization and degeneration of Purkinje Neuron Axons. Proc. Natl. Acad. Sci. 103, 5137-5142.

Bhat, M.A. 2003. Molecular organization of axo-glial junctions. Curr. Opin. Neurobiol. 13, 552-559 (featured on Cover).

Bhat, M.A. 2003. The Neurexin and NCP Gene Family. In Myelin and Its Diseases, Ed Robert Lazzarini, Elsevier Ltd.

Rios, J.C., M. Rubin, M. St. Martin, R.T. Downey, Einheber, S., J. Rosenbluth, S.R. Levinson, M. Bhat and J.L. Salzer, 2003. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. J. Neurosci. 23, 7001-7011.

Bhat, M.A., J.C. Rios, Y. Lu, G.P. Garcia-Fresco, W. Ching, M.S. Martin, S. Einheber, M. Chesler, J. Rosenbluth, J.L. Salzer, and H.J. Bellen. 2001. Axon-Glia Interactions and the Domain Organization of Myelinated Axons Requires Caspr/Paranodin. Neuron 30, 369-383 (featured on Cover).

Bellen, H. J., Y. Lu, R.B. Beckstead, and M.A. Bhat. 1998. Neurexin IV, Caspr, Paranodin, Novel Members of the Neurexin family: Encounters of Axons and Glia. Trends Neurosci. 10, 444-449.



Prokaryotic System

Bhat, M.A. and C.S. Vaidyanathan. 1994. Microbial Degradation of Halogenated Aromatics. In Biotransformations: Microbial Degradation of Health Risk Compounds. Series Progress in Industrial Microbiology, pp. 125-156, Elsevier Press.

Bhat, M.A., T. Tsuda, K. Horiike, M. Nozaki, C.S. Vaidyanathan, and T. Nakazawa. 1994. Isolation and Characterization of a New Plasmid Encoding Genes for the Degradation of 2,4-Dichlorophenoxyacetic Acid (2,4-D) from Pseudomonas cepacia CSV90. Appl. Environ. Microbiol. 60, 307-312.

Bhat, M.A., T. Ishida, H. Horiike, C.S. Vaidyanathan and M. Nozaki. 1993. Purification of 3,5-Dichlorocatechol 1,2-Dioxygenase: a Non Heme Iron Dioxygenase and a Key Enzyme in the Biodegradation of a Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4-D) from Pseudomonas cepacia CSV90. Arch. Biochem. Biophs. 300, 738-746.

Radjendirane, V., M.A. Bhat and C.S. Vaidyanathan. 1991. Affinity Purification and Characterization of 2,4-Dichlorophenol Hydroxylase from Pseudomonas cepacia CSV90. Arch. Biochem. Biophs. 288,169-176.



Plant System

Khan, N.U., M.A. Bhat and C.S. Vaidyanathan. 1989. Phenylalanine ammonia-lyase: An Update on its Kinetics. Current Science 58, 427-430.





Drosophila Model System

Banerjee, S., Mino, R., Fisher, E. and Bhat, M.A. (2017). A Versatile Genetic Tool to Study Midline Glia Function in the Drosophila CNS. Developmental Biology (in press).

Banerjee, S., Venkatesan, A. and Bhat, M.A. (2016) Neurexin, Neuroligin and Wishful Thinking Coordinate Synaptic Cytoarchitecture and Growth at Neuromuscular Junctions. Mol. Cell. Neurosci. 78, 9-24. (Featured on the Cover).

Mino, R.E., Rogers, S.L., Risinger, A.L., Rohena, C., Banerjee, S. and Bhat, M.A. (2016). Drosophila Ringmaker Regulates Microtubule Stabilization and Axonal Extension During Embryonic Development. J. Cell Sci. 129, 3282-3294.

Banerjee, S., Riordan, M. and Bhat, M.A. (2014). Genetic Aspects of Autism Spectrum Disorders: Insights from Animal Models. Frontiers in Cellular Neuroscience 8:58. 

Chen, Y.-C., Lin, Y.Q., Banerjee, S., Venken, K., Li, J., Ismat, A., Chen, K., Duraine, L., Bellen, H.J. and Bhat, M.A. (2012). Drosophila Neuroligin 2 is Required Presynaptically and Postsynaptically for proper Synaptic Differentiation and Synaptic Transmission. J. Neurosci.  32: 16018-16030.

Banerjee, S., Paik, R., Mino, R.E., Blauth, K., Fisher, E.S., Madden, V., Fanning, A. S., and Bhat, M.A. (2011). A Laminin G-EGF-Laminin G (LEL) Module in Drosophila Neurexin IV is Essential for the Apico-lateral Localization of Contactin and Organization of Septate Junctions. PLos ONE 6, e25926 (1-14). 

Choi, W., Jung, K.C., Nelson, K.S., Bhat, M.A., Beitel, G.J., Peifer, M., and Fanning AS. (2011). The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled. Mol. Biol. Cell 22, 2010-2030.

Banerjee, S., Blauth, K. Rogers, S.L., and Bhat, M.A. (2010). Drosophila Neurexin IV is Required for Repulsive Midline Axon Guidance and Functions in Concert with Roundabout and Slit. J. Neurosci. 30, 5653-5667.

Blauth, K., Banerjee, S. and Bhat, M.A. (2010). Mechanisms of Ensheathment of Peripheral Axons in Drosophila. In International Review of Cell & Molecular Biology. Ed. Kwang, J.W. Elsevier Inc. 283C, 93-128.

Wheeler, S.R., Banerjee, S., Blauth, K., Rogers, S.L., Bhat, M.A.* and Crews, S.T.* (2009). Neurexin IV and Wrapper Interactions Mediate Drosophila Midline Glial Migration and Axonal Ensheathment. Development 136, 1147-1157. (*co-corresponding authors)

Banerjee, S. and Bhat, M.A. (2008). Glial ensheathment of peripheral axons in Drosophila. J. Neurosci. Res. 86,1189-1198.

Banerjee, S., R.J. Bainton, R.B. Beckstead and Bhat, M.A. (2008). Septate Junctions are Required for Ommatidial Integrity and Blood-Eye Barrier Function in Drosophila. Dev. Biol. 317, 585-599 (featured on Cover).

Li J., Ashley J., Budnik V. and Bhat, M.A. (2007). Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission. Neuron 55, 741-755. (Featured in Faculty of 1000).

Banerjee, S. and Bhat, M.A. (2007). Neuron-glial interactions in blood-brain barrier formation. Annual Review of Neuroscience 30, 235-258.

Wu, V.M., M. Yu, R. Paik, S. Banerjee, Z. Liang, Bhat, M.A. and G.J. Beitel. (2007). Varicose encodes a member of a new subgroup of basolateral MAGUKs and is required for Drosophila septate junction function. Development 134, 999-1009.

Banerjee, S., Sousa, A.D. and Bhat, M.A. (2006). Organization and function of septate junctions: an evolutionary perspective. Cell Biochem. Biophys. 46, 65-77.

Banerjee, S., Pillai, A., Paik, R., and Bhat, M.A. (2006). Axonal Ensheathment and Septate Junction Formation in the Peripheral Nervous System of Drosophila. J. Neurosci. 26, 3319- 3329.

Faivre-Sarrailh, C., S. Banerjee, J. Li, M. Laval, M. Hortsch, and M.A. Bhat. 2004. Drosophila Contactin, a homolog of vertebrate contactin is required for septate junction organization and paracellular barrier function. Development 131, 4931-4942.

De Graeve F, Smaldone S, Laub F, Mlodzik M, Bhat M.A. and Ramirez F. 2003. Identification of the Drosophila progenitor of mammalian Kruppel-like factors 6 and 7 and a determinant of fly development. Gene 2003 18, 55-62.

Izadoost, S., S. Nam, M.A. Bhat, H.J. Bellen and K. Choi. 2002. Drosophila Crumbs is a Positional Cue in Photoreceptor Adherens Junctions and Rhabdomeres. Nature 416, 178-182.

Bhat, M.A., S. Izadoost, Y. Lu, K. Cho, K. Choi and H.J. Bellen. 1999. Discs Lost, a Novel Multi-PDZ Domain Protein, Establishes and Maintains Epithelial Polarity. Cell 96, 833-845.

Cabello, O.A., A. Baldini, M. Bhat, H. Bellen and J.W. Belmont. 1997. Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2. Genomics 46:311-313.

Wu, M., J.T. Littleton, M.A. Bhat and H.J. Bellen. 1997. Rop, the Drosophila Sec1 Homolog, Interacts with Syntaxin and Regulates Neurotransmitter Release in a Dosage Dependent manner. EMBO J. 17, 127-139.

J.T. Littleton, M.A. Bhat and H.J. Bellen. 1997. Deciphering the Function of Neurexins at Cellular Junctions. J. Cell Biol. 137, 793-796.

Bhat, M.A., A.V. Philp, D.M. Glover and H.J. Bellen. 1996. Chromatid Segregation at Anaphase Requires the barren Product, a Novel Chromosome Associated Protein that Interacts with Topoisomerase II. Cell 87, 1103-1114.

Baumgartner, S., J.T. Littleton, K. Broadie, M.A. Bhat, R. Herbecke, J.A. Lengyel, R. Chiquet- Ehrismann and H.J. Bellen. 1996. A Drosophila Neurexin is Required for Septate Junction and Blood-Nerve Barrier Formation and Function. Cell 87, 1059-1068.

Kania, A., A. Salzberg, M. A. Bhat, D. D’Evelyn, Y.-C. He and H.J. Bellen. 1994. Mutations on the Second Chromosome that Affect the Development of the Peripheral Nervous System in Drosophila. Genetics 139, 1663-1678.