Julia Saifetyarova
Postdoctoral Fellow

I obtained my PhD degree in Physiology from the Institute of Developmental Biology RAS, Moscow, Russia. My research was mainly focused on molecular and cellular mechanisms of endocrine regulation of peripheral targets by catecholamines deriving from the brain to the general circulation before the blood-brain barrier formation. 
The special area of my interests covers such problems of developmental neuroscience as neurogenesis, neuronal migration, synaptogenesis, signal transduction pathways, blood-brain barrier formation and its permeability, process of axonal myelination and its influence on neural circuits.
I am excited to be part of Professor Bhat’s Lab, where I have an opportunity to continue my research in developmental neuroscience. As a postdoctoral fellow in the Bhat Lab, I am interested in molecular mechanisms by which complex axon-glial interactions develop during mammalian ontogeny. Using mouse as a model system, we study mechanisms of how axon-glial interactions are orchestrated and axonal domains are organized. Our studies will allow a better understanding of the mechanisms of demyelinating diseases, and lead to better strategies for early diagnosis and treatment of such diseases.


Publications

Saifetiarova J, Shi Q, Paukert M, Komada M, Bhat MA (2018) Reorganization of Destabilized Nodes of Ranvier in βIV Spectrin Mutants Uncovers Critical Timelines for Nodal Restoration and Prevention of Motor Paresis. J. Neurosci. DOI: https://doi.org/10.1523/JNEUROSCI.0515-18.2018

Shi Q, Saifetiarova J, Taylor AM, Bhat MA (2018) mTORC1 Activation by Loss of Tsc1 in Myelinating Glia Causes Downregulation of Quaking and Neurofascin 155 Leading to Paranodal Domain Disorganization. Front. Cell. Neurosci. doi: 10.3389/fncel.2018.00201

Barron T, Saifetiarova J, Bhat MA, Kim JH. (2018). Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus. Sci Rep. 8(1):1022. 

Saifetiarova, J., Liu, X., Taylor, A.M., Li, J. and Bhat, M.A. (2017). Axonal Domain Disorganization in Caspr1 and Caspr2 Mutant Myelinated Axons Affects Neuromuscular Junction Integrity Leading to Muscle Atrophy. J. Neurosci. Res. DOI: 10.1002/jnr.24052

Saifetyarova, J., Taylor, A.M., and Bhat, M.A. (2017) Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. J Neurosci. 2661-16.2017  (featured on the Cover)

Taylor, A.M., Saifetyarova, J., and Bhat, M.A. (2017) Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function.  Front. Cell. Neurosci. 11:11. doi: 10.3389/fncel.2017.00011 

Saifetyarova Y.Y., Melnikova V.I., Sapronova A.Y., Volina E.V., Ugrumov M.V. (2014). The developing brain as an endocrine source of norepinephrine in the blood. Doklady Biological Sciences. V. 454(1), 5-8.
http://www.ncbi.nlm.nih.gov/pubmed/24659276

Zubova Y.O., Saifetyarova Y.Y., Sapronova A.Y., Ugryumov M.V. (2014). The chronic inhibition of dopamine synthesis in the brain of neonatal rats as an evidence of its endocrine function in ontogeny. Doklady Biological Sciences. V. 454(1), P.12-15.
http://www.ncbi.nlm.nih.gov/pubmed/24659278

Saifetyarova Y.Y., Degtyareva E.A., Sapronova A.Ya., Ugrumov M.V. Endocrine function of dopaminergic neurons in the neonatal rat brain // Neurochemical Journal. 2011. V. 5(3). P.169-175.
http://www.springerlink.com/content/v4185647522g1g37/

Ugrumov M.V., Saifetyarova J.Y., Lavrentieva A.V., Sapronova A.Y. Developing brain as an endocrine organ: secretion of dopamine // Mol. Cell. Endocrinol. 2012. V. 348(1). P.78-86. 
http://www.ncbi.nlm.nih.gov/pubmed/21827827

Saifetyarova Y.Y., Sapronova A.Y., Ugrumov M.V. Endocrine function of dopaminergic neurons of the whole rat brain in ontogeny: control of prolactin secretion. Doklady Biological Sciences. 2012. V. 443, P. 81-83. http://www.ncbi.nlm.nih.gov/pubmed/22562674